Significance of anti - GBM antibodies
نویسنده
چکیده
of proteinuria in patients with a long standing history of diabetes mellitus (DM). Primary glomerulonephritis, such as IgA nephropathy can superimpose on a background of diabetic glomerulosclerosis.1 In 1998, Tejinder et al,2 reported a case of anti glomerular basement membrane (GBM) nephritis superimposed on diabetic nephropathy in a 57 year old man. Then in 1999 Merlin et al3 reported simultaneous presentation of Goodpasture’s disease and insulin dependent diabetes mellitus. Dizard et al,4 in 2004 reported a patient with type 1 DM and Hashimoto’s
منابع مشابه
Significance of anti-glomerular basement membrane antibodies in type 2 diabetic patients.
OBJECTIVE Diabetic glomerulosclerosis is a common cause of proteinuria in patients with type 2 diabetes mellitus (DM), however, primary glomerulonephritis can superimpose on it. The aim of this study is to evaluate the significance of anti-glomerular basement membrane (GBM) antibodies in type 2 DM. METHODS We choose 60 well known Saudi patients with type 2 DM diagnosed according to American D...
متن کاملAutotopes and allotopes.
P osttransplant anti–glomerular basement membrane (GBM) nephritis is a rare but devastating complication of Alport syndrome. Although anti-GBM nephritis follows transplantation in only about 3 to 5% of Alport patients, about 75% of affected allografts are lost, and the risk of recurrence in subsequent allografts is very high. Posttransplant anti-GBM nephritis and anti-GBM nephritis in native ki...
متن کاملSequential development of pulmonary renal syndrome associated with c-ANCA 3 years after development of anti-GBM glomerulonephritis.
There is evidence that there is an association between anti-glomerular basement membrane (anti-GBM) antibodies and anti-neutrophil cytoplasmic antibodies (ANCA) in the development of pulmonary renal syndrome (PRS) [1–7]. Whether these two distinct circulating auto-antibodies have some pathological interaction remains unclear. Studies have shown that 30% of patients with anti-GBM disease will te...
متن کاملIn vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA. A possible basis for a local formation of DNA-anti-DNA complexes in systemic lupus erythematosus
In vitro, collagen and collagen-like material in GBM, were demonstrated to have a particular high affinity for any DNA tested (mammalian, bacterial, viral, and plant). GBM fixed DNA 40-80 times more than HGG and BSA and 10-40 times more than bacterial LPS. GBM has a higher affinity for SSDNA than for DSDNA. This binding was inhibited at low pH, low ionic strength, and in the presence of anionic...
متن کاملA Possible Clue for the Production of Anti-Glomerular Basement Membrane Antibody Associated with Ureteral Obstruction and Hydronephrosis
BACKGROUND Anti-glomerular basement membrane (anti-GBM) antibody-mediated glomerulonephritis (anti-GBM GN) is an autoimmune disease with rapidly progressive glomerulonephritis. Based on a case report of anti-GBM GN following hydronephrosis, we hypothesized that hydronephrosis may act as a trigger for the development of anti-GBM antibodies. PATIENTS AND METHODS We evaluated 11 patients who wer...
متن کاملCASE REPORT Alveolar haemorrhage in anti-glomerular basement membrane disease without detectable antibodies by conventional assays
Anti-glomerular basement membrane (anti-GBM) disease represents the spectrum of disease attributable to circulating anti-GBM antibodies. While active anti-GBM disease in the absence of circulating anti-GBM antibodies has been described, it is considered rare with the use of current routinely available assays. We report four subjects with features consistent with active anti-GBM antibody disease...
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تاریخ انتشار 2005